Panadol Extra

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Panadol Extra Optizorb pack shot

Extra strength for tough pain1-3

With a dual formulation that fights tough pains such as headaches,1,4 migraines,5 dental pain6and menstrual pain.1 The addition of caffeine to paracetamol enhances the pain relief effect of paracetamol.7-9

Graph showing pain-relief differences between Panadol Extra Optizorb, naproxen sodium and placebo

Similar pain relief with naproxen4

Panadol Extra Optizorb and naproxen provided significantly better pain relief vs. placebo.4 Though their pain-relief effects were similar to each other (p<0.05), paracetamol was seen to have better gastrointestinal suitability.10*

Graph showing time taken to achieve total pain relieve (TOPTAR) between Panadol Extra Optizorb and sumatriptan

Effective relief even for migraines5

In a randomised, double-blind, cross-over phase IV, controlled trial, 92 patients with migraine were given either paracetamol 1000 mg + caffeine 130 mg or sumatriptan 50 mg.5

Panadol Extra Optizorb was as efficient as sumatriptan (generally used to treat migraines) for pain relief.5

Graph showing pain relief achieved with Panadol Extra Optizorb, paracetamol alone, caffeine alone and placebo.

Significant relief from menstrual pain1

This was a single-dose, placebo-controlled, double blind three-way crossover study in women with moderate-to-severe dysmenorrhoea (n=320). The total pain relief (TOTPAR) was assessed for 1000 mg paracetamol + 130 g caffeine, 1000 mg paracetamol alone and 130 mg caffeine alone or placebo.

Two tablets of Panadol Extra Optizorb provided significantly more pain relief than standard paracetamol tablets.1

What can Panadol Extra Optizorb do for Julie?

Woman facing camera and smiling

Julie needs help for her menstrual pain

Julie is a young mum of two and works fulltime. Like her mother and grandmother, she’s suffered from primary dysmenorrhoea (menstrual pain) since her teens. Recently, Julie’s developed gastritis no thanks to her irregular meals and stressful days working and looking after the household.

She needs something to help her manage her menstrual pain effectively without aggravating her gastric problem.

Panadol Extra Optizorb with paracetamol and caffeine offers fast, effective and gentle relief for tough pains such as menstrual pain.

Recommend Panadol Extra Optizorb to fight tough pains

Panadol Extra Optizorb pack shot

Panadol Extra Optizorb

Dual “active” formulation that fights tough pains.1,3-6

Panadol Extra with Optizorb product details

  • Each tablet contains paracetamol 500 mg and caffeine 65 mg.

    Also includes excipients: Starch Pregelatinized, Povidone (K-25), Calcium Carbonate, Crospovidone, Sodium parahydroxybenzoates (sodium methyl parahydroxybenzoate (E219), sodium ethyl parahydroxybenzoate (E215) and sodium propyl parahydroxybenzoate (E217), Purified Water, Alginic Acid, Magnesium Stearate.

  • Special warnings and precautions for use

    Do not use with any other paracetamol containing products. The concomitant use with other products containing paracetamol may lead to an overdose.

    Paracetamol overdose may cause liver failure which may require a liver transplant or lead to death.

    Patients are advised to check with their doctor before use if they have a severe infection, are severely malnourished, are severely underweight, or are chronic heavy alcohol users, as this may increase the risk of metabolic acidosis.

    If symptoms persist, medical advice must be sought.

    Excessive intake of caffeine (e.g. coffee, tea and some canned drinks) should be avoided while taking this product.

    Keep out of the reach and sight of children.

    Paracetamol-caffeine is not recommended:

    • for children under the age of 12 years
    • concomitant use of drugs containing lithium (caffeine can increase the elimination of lithium from the body.)
    • concomitant use of warfarin and other coumarins which may be enhanced by prolonged regular daily use of paracetamol with increased risk of bleeding; occasional doses (of paracetamol) have no significant effect.
    • during pregnancy (caffeine is not recommended for use during pregnancy due to the possible increased risk of spontaneous abortion associated with caffeine consumption)
    • during breast feeding (caffeine in breast milk may potentially have a stimulating effect on breast fed infants but significant toxicity has not been observed)

    Contraindication

    This product is contraindicated in patients with a previous history of hypersensitivity to paracetamol, caffeine or excipients.

  • Body system

    Undesirable effect
    Paracetamol

    Blood and lymphatic system disorders

    		 Thrombocytopenia

    Immune system disorders

    Anaphylaxis

    Cutaneous hypersensitivity reactions including, among others, skin rashes, angioedema and Steven Johnson syndrome and toxic epidermal necrolysis

    Respiratory, thoracic and mediastinal disorders

    Bronchospasm in patients sensitive to aspirin and other NSAIDs

    Hepatobiliary disorders

    Hepatic dysfunction
    Caffeine

    Central nervous system

    Dizziness, headache

    Cardiac disorders

    Palpitation

    Psychiatric disorders

    Insomnia, restlessness, anxiety and irritability, nervousness

    Gastrointestinal disorders

    Gastrointestinal disturbances
    When the recommended paracetamol-caffeine dosing regimen is combined with dietary caffeine intake, the resulting higher dose of caffeine may increase the potential for caffeine-related adverse effects.

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Let’s treat it right

We’re here to support your conversations with patients and customers on responsible use of medicines so that they can treat themselves and everyday medicines the right way. Brought to you by the makers of Panadol and Voltaren.

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Man with fever

Assessment of fever in adults13,14,15

To determine if a patient has fever, the most common route of taking a temperature in adults is a thermometer placed under the tongue (oral route).

If the temperature is > 38°C, consider that the patient is febrile.

Don’t forget to ask the patient for other symptoms to determine cause of the fever, “red flag” symptoms and if they require any other treatment recommendations other than medicines for fever.

Signs and symptoms

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Managing headaches and migraines

Learn more about how to effectively manage your patients’ headaches/migraines

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